Publications :: Kolon TissueGene, Inc. (950160)

Clinical Trials

U.S. Clinical Trial Phase II

Osteoarthritis Cartilage. 2015 Jul 16. pii: S1063-4584(15)01228-5. doi: 10.1016/j.joca.2015.06.019.

R&D

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1.

BMC Musculoskelet Disord. 2015 Jun 10;16:141. doi: 10.1186/s12891-015-0599-x.

A Multicenter, Single-Blind, Phase IIa Clinical Trial to Evaluate the Efficacy and Safety of a Cell-Mediated Gene Therapy in Degenerative Knee Arthritis Patients.

Hum Gene Ther Clin Dev. 2015 Jun;26(2):125-30. doi: 10.1089/humc.2014.145. Epub 2015 Apr 17.

A placebo-controlled randomised trial to assess the effect of TGF-ß1-expressing chondrocytes in patients with arthritis of the knee.

Bone Joint J. 2015 Jul;97-B(7):924-32. doi: 10.1302/0301-620X.97B7.35852.

Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-β1 in patients with grade 3 chronic degenerative joint disease of the knee.

Osteoarthritis Cartilage. 2015 Dec;23(12):2109-18. doi: 10.1016/j.joca.2015.06.019. Epub 2015 Jul 16.

BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration.

Neuroreport. 2014 May 28;25(8):549-55. doi: 10.1097/WNR.0000000000000130.

Initial phase I safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients.

Cytotherapy. 2012 Feb;14(2):247-56. doi: 10.3109/14653249.2011.629645.

Current advances in retroviral gene therapy.

Curr Gene Ther. 2011 Jun;11(3):218-28.

Pre-clinical studies of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 (TG-C).

Cytotherapy. 2010 May;12(3):384-93. doi: 10.3109/14653240903470639.

Irradiated human chondrocytes expressing bone morphogenetic protein 2 promote healing of osteoporotic bone fracture in rats.

Tissue Eng Part A. 2009 Oct;15(10):2853-63. doi: 10.1089/ten.TEA.2008.0578.

Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-beta1- producing chondrocytes.

Tissue Eng. 2005 Sep-Oct;11(9-10):1516-26.

Retroviral gene therapy: safety issues and possible solutions.

Curr Gene Ther. 2005 Feb;5(1):25-35.

Continuous transforming growth factor beta1 secretion by cell-mediated gene therapy maintains chondrocyte redifferentiation.

Tissue Eng. 2005 Jan-Feb;11(1-2):310-8.

Construction of retroviral vectors with enhanced efficiency of transgene expression.

J Virol Methods. 2004 Nov;121(2):127-36.

Regeneration of hyaline articular cartilage with irradiated transforming growth factor beta1-producing fibroblasts.

Tissue Eng. 2004 May-Jun;10(5-6):665-72.

Regeneration of hyaline cartilage by cell-mediated gene therapy using transforming growth factor beta 1-producing fibroblasts.

Hum Gene Ther. 2001 Sep 20;12(14):1805-13.